Faculty Collaboration Database

Physical activity levels in patients on hemodialysis and healthy sedentary controls. Kidney Int 2000 Jun;57(6):2564-70

Date

06/09/2000

Pubmed ID

10844626

DOI

10.1046/j.1523-1755.2000.00116.x

Scopus ID

2-s2.0-0034036866 (requires institutional sign-in at Scopus site)   373 Citations

Abstract

BACKGROUND: Patients on dialysis have reduced exercise tolerance compared with age-matched sedentary controls. The reasons for this debility have not been fully elucidated, but physical inactivity could be a contributing factor. The purpose of the current study was to determine whether patients on hemodialysis are less active than healthy sedentary controls and to explore clinical correlates of physical activity level in a group of hemodialysis patients.

METHODS: Thirty-four hemodialysis patients and 80 healthy sedentary individuals participated in the study. Physical activity was measured for seven days with a three-dimensional accelerometer and with an activity questionnaire.

RESULTS: Vector magnitude values from the accelerometer for the dialysis and control subjects were 104,718 +/- 9631 and 161,255 +/- 6792 arbitrary units per day, respectively (P < 0.0001, mean +/- SEM). The estimated energy expenditure values derived from the questionnaire were 33.6 +/- 0.5 kcal/kg/day and 36.2 +/- 0.5 kcal/kg/day (P = 0.002). The difference between patients on dialysis and controls increased with advancing age. Among the dialysis subjects, some measures of nutritional status correlated with physical activity level, including serum albumin concentration (r = 0.58, P = 0.003), serum creatinine concentration (r = 0.37, P = 0. 03), and phase angle derived from bioelectrical impedance analysis (r = 0.40, P = 0.02).

CONCLUSIONS: Patients on hemodialysis are less active than healthy sedentary controls, and this difference is more pronounced among older individuals. There is an association between the level of physical activity and nutritional status among patients on dialysis. These findings are of great concern, given the trend toward increasing age in incident dialysis patients and the well-known association between inactivity and increased mortality in the general population.

Author List

Johansen KL, Chertow GM, Ng AV, Mulligan K, Carey S, Schoenfeld PY, Kent-Braun JA

Author

Alexander V. Ng PhD Associate Professor in the Exercise Science department at Marquette University

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Aged, 80 and over
Aging
Creatinine
Electric Impedance
Energy Metabolism
Female
Humans
Kidney Failure, Chronic
Male
Methods
Middle Aged
Motor Activity
Nutritional Status
Reference Values
Renal Dialysis
Serum Albumin
Surveys and Questionnaires