Faculty Collaboration Database

Muscle fiber type-specific myofibrillar actomyosin Ca2+ ATPase activity in multiple sclerosis. Muscle Nerve 1998 Apr;21(4):547-9

Date

04/09/1998

Pubmed ID

9533794

DOI

10.1002/(sici)1097-4598(199804)21:4<547::aid-mus18>3.0.co;2-u

Scopus ID

2-s2.0-0031918445 (requires institutional sign-in at Scopus site)   17 Citations

Abstract

Biopsies of tibialis anterior muscle were analyzed to determine if increased energy demand of contraction, as indirectly reflected by myofibrillar actomyosin Ca2+ ATPase (qATPase) activity, contributes to symptomatic fatigue in multiple sclerosis (MS). qATPase activity showed a fiber-type effect, IIax > IIa > I. Fiber-type qATPase activity, however, was not different between MS patients and healthy controls. We suggest that fatigue in MS does not reflect increased energy demand of contraction.

Author List

Castro MJ, Kent-Braun JA, Ng AV, Miller RG, Dudley GA

Author

Alexander V. Ng PhD Associate Professor in the Exercise Science department at Marquette University

MESH terms used to index this publication - Major topics in bold

Calcium
Humans
Multiple Sclerosis
Muscle Contraction
Muscle Fibers, Fast-Twitch
Muscle Fibers, Skeletal
Muscle, Skeletal
Myosins
Staining and Labeling