Faculty Collaboration Database

Donor and recipient BKV-specific IgG antibody and posttransplantation BKV infection: a prospective single-center study. Transplantation 2013 Mar 27;95(6):896-902

Date

03/21/2013

Pubmed ID

23511214

DOI

10.1097/TP.0b013e318282ba83

Scopus ID

2-s2.0-84877588361 (requires institutional sign-in at Scopus site)   49 Citations

Abstract

BACKGROUND: The study evaluated the relationship of pretransplantation BK virus (BKV)-specific donor and recipient serostatus to posttransplantation BKV infection.

METHODS: Two hundred forty adult de novo kidney-only recipients and 15 pediatric recipients were prospectively enrolled and followed for a minimum of 18 months. Pretransplantation BKV serostatus was available for 192 adult and 11 pediatric donor-recipient pairs. Based on BKV-specific IgG enzyme immunoassay ≥8 units, subjects were divided into four groups: D+R+, D+R-, D-R+, and D-R-. BKV DNA surveillance was performed at 1, 3, 6, 12, and 24 months. The outcomes studied were development of any BKV infection, viremia, and significant viremia (≥10,000 copies/mL plasma).

RESULTS: Of the 192 adult subjects (D+R- [n=41], D+R+ [n=42], D-R+ [n=41], and D-R- [n=68]), 89 of 192 developed any BKV infection and 62 of 89 developed BK insignificant viremia (n=33) and significant viremia (n=29). Any BKV infection developed in 25 of 41, 22 of 42, 17 of 41, and 25 of 68 in the D+R-, D+R+, D-R+, and D-R- groups, respectively. Any viremia (20 of 41) and significant viremia (10 of 41) seen in the D+R- group was significantly higher than other groups (P=0.014). In 11 pediatric recipients, infection was seen only in the D+R- group. Overall, infection was highest in the D+R- group and lowest in the D-R- group.

CONCLUSIONS: BKV serostatus can be used to risk stratify patients for posttransplantation infection.

Author List

Sood P, Senanayake S, Sujeet K, Medipalli R, Van-Why SK, Cronin DC, Johnson CP, Hariharan S

Author

Christopher P. Johnson MD Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Aged
Antibodies
BK Virus
Child
Enzyme-Linked Immunosorbent Assay
Female
Graft Rejection
Humans
Immunoglobulin G
Male
Middle Aged
Polyomavirus Infections
Postoperative Complications
Prospective Studies
Transplantation
Treatment Outcome
Tumor Virus Infections
Viremia