Faculty Collaboration Database

Changes in health-related quality of life in off-pump versus on-pump cardiac surgery: Veterans Affairs Randomized On/Off Bypass trial. Ann Thorac Surg 2013 Jun;95(6):1946-51

Date

03/05/2013

Pubmed ID

23453761

DOI

10.1016/j.athoracsur.2012.12.014

Scopus ID

2-s2.0-84878219525 (requires institutional sign-in at Scopus site)   18 Citations

Abstract

BACKGROUND: The relative benefits of performing coronary artery bypass graft surgery off-pump versus on-pump continue to be debated. A critical, patient-centered outcome is health-related quality of life; yet there has been limited evaluation in large-scale, multicenter trials of the off-pump versus on-pump impact upon quality of life.

METHODS: The Veterans Affairs Randomized On/Off Bypass trial randomized 2,203 nonemergent patients to off-pump or on-pump from February 2002 to May 2007. Patients completed a general quality of life survey (VR-36) and a disease-specific quality of life survey, the Seattle Angina Questionnaire (SAQ), prior to surgery, then again at 3 and 12 months post-bypass.

RESULTS: Of the 2,130 1-year survivors, 1,805 patients (85%) completed 1-year surveys. Randomization resulted in comparable baseline patient characteristics, including VR-36 and SAQ scores. At 3 months and 1-year post-procedure, there were no clinically relevant differences between off-pump and on-pump patients in any of the quality of life measures. Both groups had statistically significant, comparable improvements in the physical component scale of the VR-36, and in the SAQ scales.

CONCLUSIONS: For this trial's male, low-to-moderate risk, veteran population, there were no significant differences between off-pump and on-pump with regard to 1-year general and disease-specific quality of life outcomes. Both treatment arms experienced some improvements by 3 months, with continued improvements through 1-year post-bypass.

Author List

Bishawi M, Shroyer AL, Rumsfeld JS, Spertus JA, Baltz JH, Collins JF, Quin JA, Almassi GH, Grover FL, Hattler B, Va #517 Randomized on/off Bypass (Rooby) Study Group

Author

G Hossein Almassi MD Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aged
Cardiopulmonary Bypass
Coronary Angiography
Coronary Artery Bypass
Coronary Artery Bypass, Off-Pump
Coronary Restenosis
Coronary Stenosis
Elective Surgical Procedures
Graft Rejection
Graft Survival
Hospitals, Veterans
Humans
Male
Middle Aged
Postoperative Complications
Prospective Studies
Quality of Life
Risk Assessment
Severity of Illness Index
Survival Rate
Treatment Outcome
United States