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Mitochondrial myopathy: a rare cause of early-onset vocal fold atrophy. Ann Otol Rhinol Laryngol 2013 Mar;122(3):177-82

Date

04/13/2013

Pubmed ID

23577570

Pubmed Central ID

PMC3951151

DOI

10.1177/000348941312200306

Scopus ID

2-s2.0-84874832544 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

OBJECTIVES: We present the second published case of laryngeal involvement in mitochondrial myopathy.

METHODS: A patient with laryngeal involvement of mitochondrial myopathy is presented, together with a literature review.

RESULTS: A 41-year-old man presented with progressive breathy dysphonia. His brother had mitochondrial myopathy. Biopsy of the biceps muscle demonstrated cytochrome C oxidase-negative ragged blue fibers confirming mitochondrial myopathy. Videostroboscopy showed marked vocal fold atrophy, but subsequent injection laryngoplasty did not significantly improve the patient's voice, despite improved postoperative glottic closure.

CONCLUSIONS: Mitochondrial myopathy should be considered in the differential diagnosis of severe early-onset vocal fold atrophy.

Author List

Kelly EA, Bock JM, Peltier AC, Oh SJ, Garrett CG

Author

Jonathan Bock MD Professor in the Otolaryngology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Atrophy
Deglutition Disorders
Dysphonia
Humans
Laryngeal Muscles
Laryngoplasty
Male
Mitochondrial Myopathies
Vocal Cords