Acute leukemia with B-lymphoid and myeloid differentiation associated with an inv(5)(q13q33) in an adult patient. Cancer Genet Cytogenet 2005 Feb;157(1):62-6
Date
01/29/2005Pubmed ID
15676149DOI
10.1016/j.cancergencyto.2004.05.006Scopus ID
2-s2.0-12844251324 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
A paracentric inversion in the long arm of chromosome 5, inv(5)(q13q33), was found as a clonal abnormality in a patient with a treatment-resistant biphenotypic acute leukemia with B-lymphoid and myeloid differentiation. This cytogenetic aberration has not been reported previously in biphenotypic acute leukemia, although rearrangements of chromosome bands q13 and q33 have been implicated in the development of several hematologic malignancies. The presence of this aberration as the sole chromosomal abnormality suggests an important role in the pathogenesis of biphenotypic acute leukemia.
Author List
Butcher BW, Wilson KS, Kroft SH, Collins RH Jr, Bhushan VAuthor
Steven Howard Kroft MD Chair, Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Acute DiseaseAdult
Bone Marrow
Cell Differentiation
Chromosome Inversion
Chromosomes, Human, Pair 5
Flow Cytometry
Humans
Leukemia
Male