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Acute leukemia with B-lymphoid and myeloid differentiation associated with an inv(5)(q13q33) in an adult patient. Cancer Genet Cytogenet 2005 Feb;157(1):62-6

Date

01/29/2005

Pubmed ID

15676149

DOI

10.1016/j.cancergencyto.2004.05.006

Scopus ID

2-s2.0-12844251324 (requires institutional sign-in at Scopus site)   7 Citations

Abstract

A paracentric inversion in the long arm of chromosome 5, inv(5)(q13q33), was found as a clonal abnormality in a patient with a treatment-resistant biphenotypic acute leukemia with B-lymphoid and myeloid differentiation. This cytogenetic aberration has not been reported previously in biphenotypic acute leukemia, although rearrangements of chromosome bands q13 and q33 have been implicated in the development of several hematologic malignancies. The presence of this aberration as the sole chromosomal abnormality suggests an important role in the pathogenesis of biphenotypic acute leukemia.

Author List

Butcher BW, Wilson KS, Kroft SH, Collins RH Jr, Bhushan V

Author

Steven Howard Kroft MD Chair, Professor in the Pathology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Acute Disease
Adult
Bone Marrow
Cell Differentiation
Chromosome Inversion
Chromosomes, Human, Pair 5
Flow Cytometry
Humans
Leukemia
Male