Faculty Collaboration Database

Peripheral neuropathy incidence in inflammatory bowel disease: a population-based study. Neurology 2013 Apr 30;80(18):1693-7

Date

04/12/2013

Pubmed ID

23576624

Pubmed Central ID

PMC3716471

DOI

10.1212/WNL.0b013e3182904d16

Scopus ID

2-s2.0-84879076713 (requires institutional sign-in at Scopus site)   34 Citations

Abstract

OBJECTIVE: Our aim was to determine the incidence of peripheral neuropathy in a population-based inflammatory bowel disease (IBD) cohort from Olmsted County, Minnesota.

METHODS: We retrospectively ascertained neuropathy incidence in a population-based cohort of adult persons newly diagnosed with IBD between 1940 and 2004 in Olmsted County, Minnesota, using the medical records linkage system of the Rochester Epidemiology Project. The Kaplan-Meier method was used to estimate the cumulative incidence of neuropathy.

RESULTS: A total of 772 Olmsted County residents aged 18 to 91 years were diagnosed with IBD. After 12,476 person-years, 9 patients developed neuropathy, providing an overall incidence rate of 72 (95% confidence interval [CI] 33-137) cases per 100,000 IBD person-years. The cumulative incidence rates after 10, 20, and 30 years were 0.7% (95% CI 0.0%-1.3%), 0.7% (95% CI 0.0%-1.5%), and 2.4% (95% CI 0.6%-4.6%), respectively. Neuropathy was diagnosed after 1 to 44 years from IBD onset. Only 2 patients had active bowel disease at the time of neuropathy onset. The clinical spectrum consisted of 1) monophasic immune radiculoplexus neuropathy (comorbid diabetes in 2 of 4 patients) and 2) chronic distal sensorimotor polyneuropathy (comorbid diabetes in 2 of 5 patients).

CONCLUSIONS: Our population-based study suggests that neuropathy is uncommon in the patient population of IBD. Radiculoplexus neuropathy and sensorimotor polyneuropathy were both observed, commonly during periods of bowel disease inactivity. Clinicians should consider other etiologies of neuropathy in patients with IBD.

Author List

Figueroa JJ, Loftus EV Jr, Harmsen WS, Dyck PJ, Klein CJ

Author

Juan Jose Figueroa MD Assistant Professor in the Neurology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Aged
Aged, 80 and over
Colitis, Ulcerative
Crohn Disease
Female
Humans
Incidence
Inflammatory Bowel Diseases
Kaplan-Meier Estimate
Male
Middle Aged
Minnesota
Peripheral Nervous System Diseases
Retrospective Studies
Young Adult