Faculty Collaboration Database

Morbidities of lung cancer surgery in obese patients. J Thorac Cardiovasc Surg 2013 Aug;146(2):379-84

Date

04/27/2013

Pubmed ID

23618391

Pubmed Central ID

PMC4986510

DOI

10.1016/j.jtcvs.2013.02.083

Scopus ID

2-s2.0-84880315353 (requires institutional sign-in at Scopus site)   28 Citations

Abstract

BACKGROUND: Obesity is a risk factor for increased perioperative morbidity and mortality in surgical patients. There have been limited studies to correlate the morbidity of lung cancer resection with obesity.

METHODS: We performed a retrospective study of patients who underwent surgical resection for lung cancer at the Medical College of Wisconsin, Milwaukee, from 2006 to 2010. Data on patient demographics, weight, pathological findings, and hospital course were abstracted after appropriate institutional review board approval. Perioperative morbidity was defined as atrial fibrillation, heart failure, respiratory failure, pulmonary embolism, or any medical complications arising within 30 days after surgery. The Fisher exact test was used to test the association between body mass index (BMI) and perioperative morbidities.

RESULTS: Between 2006 and 2010, 320 lung resections were performed for lung cancer. The median age was 67 (interquartile range, 59-75) years, and 185 (57.8%) were females. A total of 121 (37.8%) of patients had a BMI lower than 25, and 199 (62.18%) patients had a BMI of 25 or higher. The 30-day mortality rate was 1.8% (n = 6) in the whole group; only 2 of these patients had a BMI of 25 or higher. Perioperative morbidity occurred in 28 (23.14%) of patients with a normal BMI and in 47 (23.61%) of patients with a BMI of 25 or higher (P = .54). Specific morbidities encountered by patients with normal versus BMI of 25 or higher were as follows: atrial fibrillation, 11 (9.09%) versus 24 (12.06%) (P = .46); pulmonary embolism, 1 (0.83%) versus 3 (1.51%) (P = 1.0); congestive heart failure, 2 (1.65%) versus 2 (1.01%) (P = .63); renal failure, 4 (3.3%) versus 2 (1.0%) (P = .29); respiratory failure, 12 (9.92%) versus 17 (8.54%) (P = .69); and acute respiratory distress syndrome, 2 (1.65%) versus 1 (0.50%) (P = .55). The median hospital stay was 5 days in the lower BMI group and 4 days in the BMI of 25 or higher group (P = .52).

CONCLUSIONS: Overweight and normal weight patients do not differ significantly in rates of perioperative morbidities, 30-day mortality, and length of stay. Our study indicates that potential curative surgical resections can be offered to even significantly overweight patients.

Author List

Dhakal B, Eastwood D, Sukumaran S, Hassler G, Tisol W, Gasparri M, Choong N, Santana-Davila R

Authors

Binod Dhakal MD Associate Professor in the Medicine department at Medical College of Wisconsin
Mario G. Gasparri MD Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Aged, 80 and over
Atrial Fibrillation
Body Mass Index
Female
Heart Failure
Humans
Length of Stay
Logistic Models
Lung Neoplasms
Male
Middle Aged
Multivariate Analysis
Obesity
Odds Ratio
Patient Selection
Pneumonectomy
Postoperative Complications
Pulmonary Embolism
Respiratory Insufficiency
Retrospective Studies
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome
Wisconsin