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The stress or heat shock (HS) response: insights from transgenic mouse models. Methods 2005 Feb;35(2):170-5

Date

01/15/2005

Pubmed ID

15649844

DOI

10.1016/j.ymeth.2004.08.008

Scopus ID

2-s2.0-11844295387   13 Citations

Abstract

Since its discovery, stress or heat shock (HS) response has been widely studied as a paradigm for gene regulation. From control of gene expression to function and involvement in pathological processes, different aspects of the stress response have received extended attention and investigation by various approaches, using small analyzing molecules, cells and organisms. This chapter is focused on animal models, such as transgenic mice that allow integrated analysis of intact organisms in physiological and pathological conditions. Genetically modified mice, developed to generate gain- and loss-of-function, are described. The challenges of using the transgenic mouse model are also discussed.

Author List

Christians ES, Benjamin IJ

Author

Ivor J. Benjamin MD Center Director, Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
DNA
Disease Models, Animal
Gene Expression Regulation
Genes, Reporter
HSP70 Heat-Shock Proteins
Heat-Shock Proteins
Hot Temperature
Humans
Mice
Mice, Knockout
Mice, Transgenic
Protein Conformation
Protein Folding
Temperature
Transgenes
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a