The stress or heat shock (HS) response: insights from transgenic mouse models. Methods 2005 Feb;35(2):170-5
Date
01/15/2005Pubmed ID
15649844DOI
10.1016/j.ymeth.2004.08.008Scopus ID
2-s2.0-11844295387 (requires institutional sign-in at Scopus site) 13 CitationsAbstract
Since its discovery, stress or heat shock (HS) response has been widely studied as a paradigm for gene regulation. From control of gene expression to function and involvement in pathological processes, different aspects of the stress response have received extended attention and investigation by various approaches, using small analyzing molecules, cells and organisms. This chapter is focused on animal models, such as transgenic mice that allow integrated analysis of intact organisms in physiological and pathological conditions. Genetically modified mice, developed to generate gain- and loss-of-function, are described. The challenges of using the transgenic mouse model are also discussed.
Author List
Christians ES, Benjamin IJAuthor
Ivor J. Benjamin MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsDNA
Disease Models, Animal
Gene Expression Regulation
Genes, Reporter
HSP70 Heat-Shock Proteins
Heat-Shock Proteins
Hot Temperature
Humans
Mice
Mice, Knockout
Mice, Transgenic
Protein Conformation
Protein Folding
Temperature
Transgenes
