Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Heat shock proteins in mammalian development. Semin Cell Dev Biol 2003 Oct;14(5):283-90

Date

02/28/2004

Pubmed ID

14986858

DOI

10.1016/j.semcdb.2003.09.021

Scopus ID

2-s2.0-0742270277   75 Citations

Abstract

Mammalian development follows a defined but adjustable program, depending on the plasticity of embryonic cells 'response to environmental changes. Heat shock proteins (Hsp) are integral part of this developmental program and gene targeting experiments have started to unravel developmental processes, which exhibit specific requirements for Hsps (e.g. Hsp70.2 for spermatogenesis). In the present paper, we will review available data on Hsp function and discuss the roles of heat shock factors (HSF), their major regulators, in mammalian development.

Author List

Christians ES, Zhou Q, Renard J, Benjamin IJ

Author

Ivor J. Benjamin MD Center Director, Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Embryonic and Fetal Development
Female
Gene Expression Regulation, Developmental
HSP70 Heat-Shock Proteins
Heat-Shock Proteins
Humans
Male
Placenta
Pregnancy
Spermatogenesis
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a