Heat shock proteins in mammalian development. Semin Cell Dev Biol 2003 Oct;14(5):283-90
Date
02/28/2004Pubmed ID
14986858DOI
10.1016/j.semcdb.2003.09.021Scopus ID
2-s2.0-0742270277 (requires institutional sign-in at Scopus site) 87 CitationsAbstract
Mammalian development follows a defined but adjustable program, depending on the plasticity of embryonic cells 'response to environmental changes. Heat shock proteins (Hsp) are integral part of this developmental program and gene targeting experiments have started to unravel developmental processes, which exhibit specific requirements for Hsps (e.g. Hsp70.2 for spermatogenesis). In the present paper, we will review available data on Hsp function and discuss the roles of heat shock factors (HSF), their major regulators, in mammalian development.
Author List
Christians ES, Zhou Q, Renard J, Benjamin IJAuthor
Ivor J. Benjamin MD Center Director, Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsEmbryonic and Fetal Development
Female
Gene Expression Regulation, Developmental
HSP70 Heat-Shock Proteins
Heat-Shock Proteins
Humans
Male
Placenta
Pregnancy
Spermatogenesis
