Faculty Collaboration Database

Stress proteins and cardiovascular disease. Mol Biol Med 1991 Apr;8(2):197-206

Date

04/01/1991

Pubmed ID

1806762

Scopus ID

2-s2.0-0026336971 (requires institutional sign-in at Scopus site)   17 Citations

Abstract

Understanding the molecular basis by which cells of the heart and blood vessels adapt to physiological stress conditions is an important goal for cardiovascular investigators. The ubiquitous heat shock response provides a model for cellular adaptations to metabolic stresses that are encountered in cardiac disease. Stress-induced synthesis of a family of highly conserved proteins serves to protect cells from injury. In addition, members of this family have essential roles in protein processing and assembly of macromolecular complexes, and in regulation of gene expression, even in unstressed cells. Research concerning the regulation and function of stress proteins potentially is pertinent to the pathophysiology of myocardial hypertrophy, remodeling, and failure, to age-related changes in the cardiovascular system, as well as to ischemic heart disease.

Author List

Williams RS, Benjamin IJ

Author

Ivor J. Benjamin MD Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Base Sequence
Coronary Circulation
Coronary Disease
DNA-Binding Proteins
Heat-Shock Proteins
Molecular Sequence Data
Transcription Factors