Decitabine in patients with newly diagnosed and relapsed acute myeloid leukemia. Leuk Lymphoma 2013 Sep;54(9):2003-7
Date
12/29/2012Pubmed ID
23270581Pubmed Central ID
PMC3888021DOI
10.3109/10428194.2012.762093Scopus ID
2-s2.0-84879783893 (requires institutional sign-in at Scopus site) 134 CitationsAbstract
Treatment options for older patients with acute myeloid leukemia (AML) and for patients with relapsed/refractory AML are limited, and outcomes are poor. Decitabine, a hypomethylating agent, is active in patients with myelodysplastic syndrome (MDS) and AML, but its optimal dose and schedule are unknown. We report the efficacy and safety of repeated 10-day cycles of decitabine 20 mg/m(2) administered intravenously over 1 h in 52 newly diagnosed and 102 relapsed/refractory patients. Repeated 10-day cycles of decitabine produced a complete response (CR) in 40% of newly diagnosed older patients with AML, many of whom had adverse prognostic features. The median overall survival (OS) was 318 days but there was prolonged survival in responders of 481 days. Relapsed/refractory patients had a CR rate of 15.7% with a median OS of 177 days. Extramedullary toxicity was mild and the regimen was well tolerated for ongoing post-remission, outpatient maintenance cycles. Responses were durable for over 1 year.
Author List
Ritchie EK, Feldman EJ, Christos PJ, Rohan SD, Lagassa CB, Ippoliti C, Scandura JM, Carlson K, Roboz GJAuthor
Karen-Sue B. Carlson MD, PhD Associate Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedAged, 80 and over
Antimetabolites, Antineoplastic
Antineoplastic Combined Chemotherapy Protocols
Azacitidine
Cohort Studies
Female
Humans
Leukemia, Myeloid, Acute
Male
Middle Aged
Recurrence
Remission Induction
Treatment Outcome
