Advances in the diagnosis and treatment of pheochromocytoma. Arch Surg 1988 May;123(5):626-30
Date
05/01/1988Pubmed ID
3282495DOI
10.1001/archsurg.1988.01400290112020Scopus ID
2-s2.0-0023925626 (requires institutional sign-in at Scopus site) 28 CitationsAbstract
Diagnosis and management of pheochromocytoma, once dangerous and uncertain, have been dramatically altered in recent years by advances in imaging, assays, and pharmaceuticals. During the past ten years we have treated 18 patients who had pheochromocytoma. Biochemical diagnosis was made in all patients by measurement of 24-hour urinary total catecholamine excretion or by epinephrine-norepinephrine fractionation. Determination of epinephrine-norepinephrine ratios was instrumental in making the diagnosis of pheochromocytoma in two patients in whom total catecholamine levels were normal. Localization of the pheochromocytoma in the most recently treated cases was accomplished by ultrasound, computed tomography, or iodine I 131 iobenguane (iodine I 131 metaiodobenzylguanidine) scanning. Nine patients in the series were prepared for surgery with phenoxybenzamine hydrochloride and six with prazosin hydrochloride. Preoperative total alpha-adrenergic blockade with phenoxybenzamine offered no advantage over selective blockade with prazosin in terms of perioperative fluid requirements or intraoperative hemodynamic stability.
Author List
Havlik RJ, Cahow CE, Kinder BKAuthor
Robert Havlik MD Chair, Professor in the Plastic Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Adrenal Gland NeoplasmsAdult
Female
Humans
Male
Middle Aged
Phenoxybenzamine
Pheochromocytoma
Prazosin
Preoperative Care
Ultrasonography
