Activation of human medial prefrontal cortex during autonomic responses to hypoglycemia. Proc Natl Acad Sci U S A 2004 Apr 20;101(16):6217-21
Date
03/18/2004Pubmed ID
15026569Pubmed Central ID
PMC395949DOI
10.1073/pnas.0307048101Scopus ID
2-s2.0-1942469342 (requires institutional sign-in at Scopus site) 123 CitationsAbstract
Studies in humans implicate the medial prefrontal cortex (MPFC) in complex cognitive and emotional states. We measured regional cerebral blood flow (CBF) four times each during euglycemia (5.2 +/- 0.2 mmol/liter) and hypoglycemia (3.0 +/- 0.3 mmol/liter) in nine normal human volunteers. Autonomic responses during hypoglycemia were manifested by increases in neurogenic symptoms, heart rate, and plasma levels of epinephrine, norepinephrine, and pancreatic polypeptide. Typical symptoms of hypoglycemia were mild, and none reflected evidence of cognitive or emotional stress. Quantitative CBF fell 6-8% in the cerebrum, brainstem, and cerebellum. Analysis of regional CBF differences identified neuronal activation during hypoglycemia in bilateral MPFC (areas 24 and 32) and bilateral thalamus. These results provide evidence that the MPFC participates in the autonomic responses to simple physiological stimuli in humans.
Author List
Teves D, Videen TO, Cryer PE, Powers WJAuthor
Denise Teves Qualler MD Associate Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Autonomic Nervous System
Cerebrovascular Circulation
Female
Humans
Hypoglycemia
Magnetic Resonance Imaging
Male
Prefrontal Cortex
Tomography, Emission-Computed
