Comparability of functional MRI response in young and old during inhibition. Neuroreport 2004 Jan 19;15(1):129-33
Date
04/27/2004Pubmed ID
15106844Pubmed Central ID
PMC2078238DOI
10.1097/00001756-200401190-00025Scopus ID
2-s2.0-3042703222 (requires institutional sign-in at Scopus site) 32 CitationsAbstract
When using fMRI to study age-related cognitive changes, it is important to establish the integrity of the hemodynamic response because, potentially, it can be affected by age and disease. However, there have been few attempts to document such integrity and no attempts using higher cognitive rather than perceptual or motor tasks. We used fMRI with 28 healthy young and older adults on an inhibitory control task. Although older and young adults differed in task performance and activation patterns, they had comparable hemodynamic responses. We conclude that activation during cognitive inhibition, which was predominantly increased in elders, was not due to vascular confounds or specific changes in hemodynamic coupling.
Author List
Nielson KA, Langenecker SA, Ross TJ, Garavan H, Rao SM, Stein EAAuthor
Kristy Nielson PhD Professor in the Psychology department at Marquette UniversityMESH terms used to index this publication - Major topics in bold
AdultAged
Aging
Cognition
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Psychomotor Performance
