Pathophysiology of stroke in sickle cell disease. Microcirculation 2004 Mar;11(2):195-208
Date
07/29/2004Pubmed ID
15280092DOI
10.1080/10739680490278600Scopus ID
2-s2.0-3242753073 (requires institutional sign-in at Scopus site) 72 CitationsAbstract
Stroke affects both motor and cognitive function in patients with sickle cell disease (SCD). Symptomatic stroke is associated with intimal disease of the large cerebral arteries. Silent stroke, defined as cerebral infarction in the absence of overt clinical neurologic symptoms, is often due to microinfarcts suggestive of microvascular disease. While the natural history of stroke in SCD is well described, the pathophysiology remains poorly understood and probably varies with the site of vascular injury. Increased red cell adhesion, oxidative injury of the vessel wall, inflammation, abnormal vasomotor tone regulation, and increased activity of the coagulation system all may contribute to cerebral vasopathology in SCD.
Author List
Hillery CA, Panepinto JAMESH terms used to index this publication - Major topics in bold
Anemia, Sickle CellAnimals
Blood Coagulation
Cell Adhesion
Cerebral Arteries
Cerebral Infarction
Cerebrovascular Circulation
Erythrocytes, Abnormal
Humans
Inflammation
Oxidative Stress
