Faculty Collaboration Database

Biomimetic mineralization: long-term observations in patients with dentin sensitivity. Dent Mater 2012 Apr;28(4):457-64

Date

02/07/2012

Pubmed ID

22305715

DOI

10.1016/j.dental.2012.01.003

Scopus ID

2-s2.0-84858070106 (requires institutional sign-in at Scopus site)   31 Citations

Abstract

OBJECTIVE: Cervical tooth erosion is increasingly observed among adults and frequently associated with dentin sensitivity (DS). This study evaluated the effectiveness on DS of a biomimetic mineralization system (BIMIN) in comparison to the current standard treatment (Gluma(®) Desensitizer, Gluma).

METHODS: In this single-blind, 2-arm study, 40 patients with confirmed cervical DS were randomized to either the test group or the positive control group. A Visual-Analog-Scale (VAS) was used to assess DS following stimulation of the exposed dentin with a 2-s air blast. Assessments were made at baseline (pre-treatment), 2 days, 4, 8 and 12 weeks, and 12 months after treatment. Two-stage replicas were obtained from the treated teeth and gold sputtered at baseline, and 2 days, 3 and 12 months after treatment. Surface topography of the treated cervical lesions and occlusion of dentinal tubules were investigated using scanning electron microscopy (SEM).

RESULTS: Both treatments led to a statistically significant reduction (P<0.0001) in DS that persisted over the entire 12-month observation period. Differences in DS between the treatments were not statistically significant. SEM photomicrographs demonstrated that a mineral layer concealed the dentinal tubules in the test group. In contrast, numerous dentinal tubules remained visible in cervical defects that were treated with Gluma.

SIGNIFICANCE: A biomimetic mineralization kit was successfully used to treat patients exhibiting DS. The effect was similar to using Gluma, and was likely the result of the deposition of an enamel-like layer on the exposed cervical dentin.

Author List

Guentsch A, Seidler K, Nietzsche S, Hefti AF, Preshaw PM, Watts DC, Jandt KD, Sigusch BW

Authors

Arndt Geuntsch in the CTSI department at Medical College of Wisconsin - CTSI
Arthur Hefti DDS,PhD Associate Dean - Research & Graduate Studies in the Dentistry department at Marquette University

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Apatites
Biomimetic Materials
Calcium
Dentin
Dentin Desensitizing Agents
Dentin Permeability
Dentin Sensitivity
Female
Fluorides
Glutaral
Humans
Male
Microscopy, Electron, Scanning
Middle Aged
Phosphates
Polymethacrylic Acids
Replica Techniques
Single-Blind Method
Tooth Cervix
Tooth Erosion
Tooth Remineralization
Treatment Outcome
Young Adult