Faculty Collaboration Database

Subantimicrobial dose doxycycline as an adjunct to scaling and root planing: post-treatment effects. J Clin Periodontol 2001 Aug;28(8):782-9

Date

07/10/2001

Pubmed ID

11442739

DOI

10.1034/j.1600-051x.2001.280810.x

Scopus ID

2-s2.0-18044404771 (requires institutional sign-in at Scopus site)   71 Citations

Abstract

BACKGROUND/OBJECTIVE: Subantimicrobial dose doxycycline (SDD 20 mg bid) plus scaling and root planing (SRP) significantly improved clinical attachment level (CAL) and reduced probing depth (PD) compared with placebo plus SRP in a double-blind, placebo-controlled, multicenter study of patients with adult periodontitis (AP). In a study conducted as a follow-up, the post-treatment effects of SDD were assessed in patients who completed the SRP study.

METHODS: The SRP study was a 9-month, active-treatment study and the follow-up was a 3-month, no-treatment study. In the SRP study, tooth sites in qualifying quadrants were scaled and root planed and patients were randomized to receive twice daily SDD 20 mg or placebo. In the follow-up, patients received no study drug; investigators and patients remained blinded to the previous treatment group assignments. Efficacy measures included the change in CAL and PD from baseline values determined at the start of the SRP study in tooth sites stratified by baseline PD (i.e., 0-3 mm, 4-6 mm, > or =7 mm). Safety was evaluated using adverse event data and the results of clinical laboratory tests, oral pathology examinations, and microbiological assessments.

RESULTS: Within each disease stratum, the incremental improvements in PD and CAL demonstrated in the SDD group over 9 months of active treatment were maintained through 3 additional months of no treatment. Treatment cessation did not result in an accelerated regression of periodontal health. No differences in the incidence of adverse events (including those related to infection) or laboratory or microbiological parameters were noted between the SDD group and the placebo group.

CONCLUSIONS: The administration of SDD 20 mg bid for a period of up to 9 months is not associated with rebound effects or delayed or negative after-effects for a 3-month period after cessation of therapy.

Author List

Caton JG, Ciancio SG, Blieden TM, Bradshaw M, Crout RJ, Hefti AF, Massaro JM, Polson AM, Thomas J, Walker C

Author

Arthur Hefti DDS,PhD Associate Dean - Research & Graduate Studies in the Dentistry department at Marquette University

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Anti-Bacterial Agents
Dental Scaling
Dose-Response Relationship, Drug
Double-Blind Method
Doxycycline
Female
Follow-Up Studies
Humans
Male
Matrix Metalloproteinases
Middle Aged
Periodontal Index
Periodontitis
Randomized Controlled Trials as Topic
Root Planing
Treatment Outcome