[Acceleration of orthodontically induced tooth movement through the local application of prostaglandin (PGE1)]. Schweiz Monatsschr Zahnmed 1989;99(2):162-5
Date
01/01/1989Pubmed ID
2717904Scopus ID
2-s2.0-0024488519 (requires institutional sign-in at Scopus site) 19 CitationsAbstract
A preliminary study was designed to assess the effect of prostaglandin E1 on tooth movement. In 5 patients palatal attachments were bonded on corresponding upper left and right premolars which were to be extracted later in the course of routine orthodontic treatment. A transpalatal elastic exerted reciprocal force on the teeth. Following local anaesthesia, 0.1 ml of a 0.01% (w/v) PGE1 solution in saline was injected under the mucoperiosteum palatal to the test tooth and 0.1 ml saline palatal to the contralateral control tooth. Injections were repeated at weekly intervals. On average, the PGE1-treated teeth moved 3 times faster than the controls but the rate of movement differed individually. Clinical and x-ray examinations of the teeth involved in the study as well as the surrounding tissues showed no evidence of pathologic changes. No negative side effects were noticed by the patients. Despite positive experiences, this treatment is not to be recommended for use in dental offices yet.
Author List
Spielmann T, Wieslander L, Hefti AFAuthor
Arthur Hefti DDS,PhD Associate Dean - Research & Graduate Studies in the Dentistry department at Marquette UniversityMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Alprostadil
Child
Drug Evaluation
Female
Humans
Injections
Male
Orthodontic Appliances
Periodontal Ligament
Tooth Movement Techniques
