Faculty Collaboration Database

Are Actinomyces viscosus antigens B cell mitogens? J Immunol 1977 Apr;118(4):1460-5

Date

04/01/1977

Pubmed ID

300408

Scopus ID

2-s2.0-0017653251 (requires institutional sign-in at Scopus site)   30 Citations

Abstract

An extracellular heteroglycan (ECHG) and a sonicated cell supernatant (SCS) of Actinomyces viscosus Ny 1 induced strong lymphocyte proliferation. This was shown with spleen and thoracic duct cells form germfree rats and confirmed with cells from conventional "nude" mouse spleens. Spleen cells developed direct plaque-forming cells against densely coupled TNP-SRBC. The mitogenic property of ECHG was diminished considerably after mild alkaline hydrolysis for lymphocytes form rat spleens and was totally abolished for cells from "nude" mouse spleens. These results suggest that ECHG and SCS have B cell mitogenicity.

Author List

Burckhardt JJ, Guggenheim B, Hefti A

Author

Arthur Hefti DDS,PhD Associate Dean - Research & Graduate Studies in the Dentistry department at Marquette University

MESH terms used to index this publication - Major topics in bold

Actinomyces
Alkalies
Animals
Antibody-Producing Cells
Antigens, Bacterial
B-Lymphocytes
Cell Division
Female
Germ-Free Life
In Vitro Techniques
Lymphocyte Activation
Male
Mice
Mice, Nude
Mitogens
Polysaccharides, Bacterial
Rats
Spleen
Thoracic Duct
Thymidine
Uridine