Prevention of cold-induced increase in blood pressure of rats by captopril. Hypertension 1991 Jun;17(6 Pt 1):763-70
Date
06/01/1991Pubmed ID
2045137DOI
10.1161/01.hyp.17.6.763Scopus ID
2-s2.0-0026042573 (requires institutional sign-in at Scopus site) 44 CitationsAbstract
To assess the possibility that the renin-angiotensin system may play a role in the development of cold-induced hypertension, three groups of rats were used. Two groups were exposed to cold (5 +/- 2 degrees C) while the remaining group was kept at 26 +/- 2 degrees C. One group of cold-treated rats received food into which captopril (0.06% by weight) had been thoroughly mixed. The remaining two groups received the same food but without captopril. Systolic blood pressure of the untreated, cold-exposed group increased significantly above that of the warm-adapted, control group within 4 weeks of exposure to cold. In contrast, chronic treatment with captopril prevented the elevation of blood pressure. Rats were killed after 4 months of exposure to cold. At death, the heart, kidneys, adrenal glands, and interscapular brown fat pad were removed and weighed. Although captopril prevented the elevation of blood pressure in cold-treated rats, it did not prevent hypertrophy of the kidneys, heart, and interstitial brown adipose tissue that characteristically accompanies exposure to cold. Thus, chronic treatment with captopril prevented the elevation of blood pressure when administered at the time exposure to cold was initiated. It also reduced the elevated blood pressure of cold-treated rats when administered after blood pressure became elevated. This suggests that the renin-angiotensin system may play a role in the elevation of blood pressure during exposure to cold.
Author List
Shechtman O, Fregly MJ, van Bergen P, Papanek PEAuthor
Paula Papanek PhD, MPT, LAT, FACSM Associate Professor & Director of Exercise Science in the Exercise Science & Physical Therapy department at Marquette UniversityMESH terms used to index this publication - Major topics in bold
AnimalsBlood Pressure
Captopril
Cold Temperature
Hypertension
Male
Organ Specificity
Rats
Rats, Inbred Strains
Renin-Angiotensin System
