Prevalence of oral lesions and percent CD4+ T-lymphocytes in HIV-infected children on antiretroviral therapy. AIDS Patient Care STDS 2003 Jan;17(1):5-11
Date
03/05/2003Pubmed ID
12614515DOI
10.1089/108729103321042863Scopus ID
2-s2.0-0037231423 (requires institutional sign-in at Scopus site) 23 CitationsAbstract
This study examined prevalence of oral lesions and how it relates to CD4 percentages in vertically infected children with HIV undergoing combination antiretroviral therapy. One hundred two HIV-infected children between the ages of 3 and 15 years attending a specialized pediatric outpatient clinic were examined for oral lesions, and their CD4 percent and viral load extracted from their medical records. Of the 102 HIV-infected children, 69% had evidence of oral pathology and 31% were disease free. The proportion with disease was: 20.6% had conventional gingivitis, 19.6% had dental caries in their primary and permanent teeth combined, 13.7% had depapillated tongue, 3.9% had early childhood caries, 2.9% had oral candidiasis, 2% had bilateral enlarged parotid gland, 1% had median rhomboid glossitis, 1% had enlarged cervical lymph nodes and 2% had other developmental abnormalities. In the group with no evidence of suppression 15% had gingival lesion, 14% tongue lesion, and 1% parotid enlargement, and in the severe suppression group 55% had gingival lesion, 45% had tongue lesion, 9% had enlarged cervical lymph nodes, and another 9% had parotid gland enlargement. The association between conventional gingivitis and low CD4 percent was statistically significant (p = 0.001). Compared to previous studies, overall prevalence estimates of oral lesions in this study was low. Children with low CD4 percent had more oral lesions, consistent with results from other HIV studies.
Author List
Okunseri C, Badner V, Wiznia A, Rosenberg MAuthor
Christopher Okunseri DDS,MS Associate Professor and Director in the Clinical Services department at Marquette UniversityMESH terms used to index this publication - Major topics in bold
AdolescentAntiretroviral Therapy, Highly Active
CD4 Lymphocyte Count
Candidiasis, Oral
Child
Child, Preschool
Female
Gingivitis
HIV Infections
Humans
Male
Mouth Diseases
New York City
Outpatient Clinics, Hospital
Prevalence
Stomatitis
