Faculty Collaboration Database

Protection of the ischaemic myocardium by L-propionylcarnitine: effects on the recovery of cardiac output after ischaemia and reperfusion, carnitine transport, and fatty acid oxidation. Cardiovasc Res 1986 Jul;20(7):536-41

Date

07/01/1986

Pubmed ID

3779750

DOI

10.1093/cvr/20.7.536

Scopus ID

2-s2.0-85047675973 (requires institutional sign-in at Scopus site)   135 Citations

Abstract

The effects of L-propionylcarnitine on the recovery of cardiac contractile performance after global ischaemia and reperfusion were studied in isolated perfused rat hearts. The addition of either 5.5 or 11 mmol X litre-1 L-propionylcarnitine significantly improved the recovery of cardiac output, left ventricular pressure, and dP/dt after 90 min of ischaemia and 15 min of reperfusion. Myocardial adenosine triphosphate and creatine phosphate concentrations were significantly higher in the L-propionylcarnitine treated hearts than in controls, but the concentrations of long chain acyl carnitine and coenzyme A were unaffected. The protecting effects of L-propionylcarnitine were compared with those of L-carnitine and L-acetylcarnitine. A 11 mmol X litre-1 dose of L-propionylcarnitine and L-acetylcarnitine significantly improved the recovery of cardiac output after 90 min of ischaemia and 15 min of reperfusion, but L-carnitine did not. L-Propionylcarnitine was the most protective agent. The effects of these derivatives on L-3H-carnitine transport and 14C-palmitate oxidation were also measured. All of these derivatives competitively inhibited L-3H-carnitine transport in isolated cardiac myocytes, but L-propionylcarnitine was the most potent. Carnitine and L-propionylcarnitine stimulated palmitate oxidation in the homogenate, whereas L-acetylcarnitine inhibited it. In myocytes only L-propionylcarnitine affected palmitate oxidation. These data show that L-propionylcarnitine protects the ischaemic myocardium. Its protection is greater than that for L-carnitine or L-acetylcarnitine, and the difference in effectiveness may relate to the rate of transport into the cells and the effects on fatty acid utilisation.

Author List

Paulson DJ, Traxler J, Schmidt M, Noonan J, Shug AL

Author

John Traxler MD Assistant Professor in the Rader School of Business department at Milwaukee School of Engineering

MESH terms used to index this publication - Major topics in bold

Acetylcarnitine
Adenosine Triphosphate
Animals
Blood Pressure
Cardiac Output
Carnitine
Coronary Disease
Fatty Acids
Male
Myocardial Contraction
Myocardium
Oxidation-Reduction
Palmitic Acid
Palmitic Acids
Phosphocreatine
Rats
Rats, Inbred Strains