Effects of low-level light therapy on streptozotocin-induced diabetic kidney. J Photochem Photobiol B 2010 May 03;99(2):105-10
Date
04/02/2010Pubmed ID
20356759DOI
10.1016/j.jphotobiol.2010.03.002Scopus ID
2-s2.0-77951253678 (requires institutional sign-in at Scopus site) 27 CitationsAbstract
Hyperglycemia causes oxidative damage in tissues prone to complications in diabetes. Low-level light therapy (LLLT) in the red to near infrared range (630-1000nm) has been shown to accelerate diabetic wound healing. To test the hypothesis that LLLT would attenuate oxidative renal damage in Type I diabetic rats, male Wistar rats were made diabetic with streptozotocin (50mg/kg, ip), and then exposed to 670nm light at a dose of 9J/cm(2) once per day for 14weeks. The activity and expression of catalase and the activity of Na K-ATPase increased in kidneys of light-treated diabetic rats, whereas the activity and expression of glutathione peroxidase and the expression of Na K-ATPase were unchanged. LLLT lowered the values of serum BUN, serum creatinine, and BUN/creatinine ratio. In addition, LLLT augmented the activity and expression of cytochrome c oxidase, a primary photoacceptor molecule in the mitochondrial respiratory chain, and reduced the formation of the DNA adduct 8-hydroxy-2'-deoxyguanosine in kidney. LLLT improved renal function and antioxidant defense capabilities in the kidney of Type I diabetic rats. Thus, 670nm LLLT may be broadly applicable to the amelioration of renal complications induced by diabetes that disrupt antioxidant defense mechanisms.
Author List
Lim J, Sanders RA, Snyder AC, Eells JT, Henshel DS, Watkins JB 3rdAuthor
Janis Eells PhD Professor in the Biomedical Sciences department at University of Wisconsin - MilwaukeeMESH terms used to index this publication - Major topics in bold
AnimalsBlood Urea Nitrogen
Catalase
Creatine
Diabetes Mellitus, Experimental
Glutathione Peroxidase
Infrared Rays
Kidney
Male
Phototherapy
Rats
Rats, Wistar
Sodium-Potassium-Exchanging ATPase
