Faculty Collaboration Database

Neonatal dexamethasone therapy: short- and long-term consequences. Trends Endocrinol Metab 2004 Oct;15(8):351-2

Date

09/24/2004

Pubmed ID

15380804

DOI

10.1016/j.tem.2004.08.003

Scopus ID

2-s2.0-4544346832 (requires institutional sign-in at Scopus site)   27 Citations

Abstract

The discovery of the adrenal steroid hormones was one of the momentous events of science and medicine in the 20th century, highlighted by the awarding of the Nobel Prize in Physiology or Medicine to Kendall, Reichstein and Hench in 1950. Therapy using endogenous and synthetic corticosteroids was thought to be a miracle cure for several illnesses. We now recognize the many short- and long-term side effects of glucocorticoid therapy in neonates, children and adults, including growth retardation, insulin resistance, metabolic disturbances, cognitive and psychological problems, rapidly-progressing and profound osteoporosis, and iatrogenic Cushing's syndrome. Significant attention is now being paid to the long-term consequences of glucocorticoid therapy in premature and full-term neonates.

Author List

Raff H

Author

Hershel Raff PhD Professor in the Academic Affairs department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Animals, Newborn
Dexamethasone
Female
Glucocorticoids
Humans
Infant, Newborn
Male
Time Factors