Characterization of incidentally identified minute clonal B-lymphocyte populations in peripheral blood and bone marrow. Am J Clin Pathol 2004 Oct;122(4):588-95
Date
10/19/2004Pubmed ID
15487458DOI
10.1309/6UGD-U03V-VD0L-98LQScopus ID
2-s2.0-85047693469 (requires institutional sign-in at Scopus site) 18 CitationsAbstract
We describe 69 patients in whom small clonal B-cell populations were detected incidentally in blood and bone marrow samples by flow cytometric studies. In 20 patients (29%), non-Hodgkin lymphoma (NHL) subsequently was diagnosed 0 to 40 months (median, 0.1 month) from initial flow cytometric studies. In 49 patients (71%), there was no evidence of NHL after 0.5 to 72 months (median, 16 months). Patients without overt NHL had a higher absolute WBC count than patients with NHL (2,260/microL vs 1,470/microL [2.26 vs 1.47 x 10(9)/L]; P < .01). Otherwise, there were no clinical or hematologic differences between the 2 groups. We identified 70 clonal populations in the 69 patients, ranging from 0.05% to 4.5% (median, 1.28%) of events. The mean percentage of clonal B cells was similar for the 2 groups. The populations were CD5-/CD10- in 34 cases; CD5+, chronic lymphocytic leukemia-like in 19; CD5+, indeterminate in 9; CD10+ in 3; hairy cell leukemia-like in 3; and CD5+, mantle cell lymphoma-like in 2. There were no immunophenotypic differences in patients with and without overt NHL.
Author List
Chen W, Asplund SL, McKenna RW, Kroft SHAuthor
Steven Howard Kroft MD Chair, Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAged
Aged, 80 and over
B-Lymphocytes
Bone Marrow Cells
Disease Progression
Female
Flow Cytometry
Follow-Up Studies
Humans
Immunophenotyping
Lymphoma, Non-Hodgkin
Male
Middle Aged
Retrospective Studies
