Correlates of the FTO gene variant (rs9939609) and growth of American Indian infants. Genet Test Mol Biomarkers 2011 Sep;15(9):633-8
Date
04/16/2011Pubmed ID
21491999Pubmed Central ID
PMC3168980DOI
10.1089/gtmb.2010.0188Scopus ID
2-s2.0-84874964014 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
AIM: Obesity is a global, growing public-health problem. The detrimental health consequences of obesity are significant and include co-morbidities such as diabetes, coronary heart disease, and some types of cancer. To date, findings relating the A allele of the FTO variant rs9939609 to increased energy intake and risk for obesity have been fairly consistent across multiple populations. However, it is not known whether that relationship is also present in American Indian (AI) populations. The purpose of this study was to examine the minor allele frequency of the FTO variant rs9939609 and its associations with birth weight, weight for length (WFL) Z score, and amount of formula intake in AI infants.
DESIGN: A cross-sectional exploratory descriptive design was applied with a sample of 49 AI mother-infant dyads.
RESULTS: Mothers with an A allele had higher prepregnancy body mass index than those without an A allele, though difference was not statistically significant (p=0.08). Infants with an A allele tended to have higher birth weights, WFL Z score at age 14 to 20 weeks, and 24-h formula consumption compared with infants without an A-allele, though those differences were not statistically significant (p>0.05). Neither maternal nor infant A alleles were statistically significantly associated with birth weight, WFL Z score, and amount of formula intake in AI infants (p>0.05).
CONCLUSIONS: The findings do not confirm the association of the A allele of the FTO variant rs9939609 with birth weight, amount of formula intake, and WFL Z score in AI infants.
Author List
Seal N, Weaver M, Best LGAuthor
Nuananong Seal PhD Assistant Professor in the Nursing department at University of Wisconsin - MilwaukeeMESH terms used to index this publication - Major topics in bold
AdultAlpha-Ketoglutarate-Dependent Dioxygenase FTO
Birth Weight
Body Weight
Child Development
Cross-Sectional Studies
Female
Genetic Association Studies
Genetic Predisposition to Disease
Growth and Development
Humans
Indians, North American
Infant
Male
Obesity
Pilot Projects
Polymorphism, Single Nucleotide
Proteins
Young Adult
