Faculty Collaboration Database

Giant fetal magnetocardiogram P waves in congenital atrioventricular block: a marker of cardiovascular compensation? Circulation 2004 Oct 12;110(15):2097-101

Date

10/07/2004

Pubmed ID

15466645

DOI

10.1161/01.CIR.0000144302.30928.AA

Scopus ID

2-s2.0-5644221306 (requires institutional sign-in at Scopus site)   27 Citations

Abstract

BACKGROUND: Cardiogram signal amplitude is a key index of hypertrophy but has not been investigated extensively in utero. In this study, magnetocardiography was used to assess P and QRS amplitude in normal subjects and subjects with fetal arrhythmia.

METHODS AND RESULTS: The study cohort consisted of 68 normal fetuses and 25 with various arrhythmias: 9 reentrant supraventricular tachycardia (SVT), 2 ventricular tachycardia (VT), 2 sinus tachycardia, 2 blocked atrial bigeminy, 2 congenital second-degree atrioventricular (AV) block, and 8 congenital complete AV block. Subjects with congenital AV block, all presenting with bradycardia, showed large QRS amplitude, exceedingly large P-wave amplitude, and long P-wave duration. The 2 subjects with VT, both with poor ventricular function, also exhibited large P waves. SVT was associated with only moderate signal amplitude elevation.

CONCLUSIONS: The data imply that AV block in utero is accompanied by hypertrophy, which is more pronounced for the atria than the ventricles. We hypothesize that the hypertrophy results from a compensatory response associated with regulation of cardiac output and is likely to be observable in other arrhythmias and disease states. Magnetocardiography may be more sensitive than fetal echocardiography for detection of atrial hypertrophy in utero.

Author List

Li Z, Strasburger JF, Cuneo BF, Gotteiner NL, Wakai RT

Author

Janette F. Strasburger MD Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Bradycardia
Cardiac Output
Cardiomegaly
Cohort Studies
Fetal Heart
Gestational Age
Heart Block
Heart Conduction System
Heart Function Tests
Humans
Magnetics
Tachycardia, Sinus
Tachycardia, Supraventricular
Tachycardia, Ventricular