Faculty Collaboration Database

Anatomic distribution of pulmonary vascular compliance. J Appl Physiol (1985) 1998 Jan;84(1):303-10

Date

02/06/1998

Pubmed ID

9451650

DOI

10.1152/jappl.1998.84.1.303

Scopus ID

2-s2.0-2642644570 (requires institutional sign-in at Scopus site)   26 Citations

Abstract

Previously, the pressure changes after arterial and venous occlusion have been used to characterize the longitudinal distribution of pulmonary vascular resistance with respect to vascular compliance using compartmental models. However, the compartments have not been defined anatomically. Using video microscopy of the subpleural microcirculation, we have measured the flow changes in approximately 40-micron arterioles and venules after venous, arterial, and double occlusion maneuvers. The quasi-steady flows through these vessels after venous occlusion permitted an estimation of the compliance in three anatomic segments: arteries > 40 microns, veins > 40 microns, and vessels < 40 microns in diameter. We found that approximately 65% of the total pulmonary vascular compliance was in vessels < 40 microns, presumably mostly capillaries. The transient portions of the pressure and flow data after venous, arterial, and double occlusion were consistent with most of the arterial compliance being upstream from most of the arterial resistance and most of the venous compliance being downstream from most of the venous resistance.

Author List

Presson RG Jr, Audi SH, Hanger CC, Zenk GM, Sidner RA, Linehan JH, Wagner WW Jr, Dawson CA

Author

Said Audi PhD Professor in the Biomedical Engineering department at Marquette University

MESH terms used to index this publication - Major topics in bold

Animals
Blood Gas Analysis
Dogs
Image Processing, Computer-Assisted
Lung
Lung Compliance
Male
Microcirculation
Microscopy, Video
Models, Biological
Pulmonary Circulation
Respiratory Mechanics