Faculty Collaboration Database

Molecular aspects, physiological function, and clinical significance of metallothioneins. Crit Rev Food Sci Nutr 1988;27(1):41-85

Date

01/01/1988

Pubmed ID

3293923

DOI

10.1080/10408398809527477

Scopus ID

2-s2.0-0023728860 (requires institutional sign-in at Scopus site)   84 Citations

Abstract

Metallothioneins (MTs) are well-characterized low molecular weight, heat-stable cytosolic proteins with exceptional high content of cysteinyl sulfur and are known to bind heavy metals like cadmium (Cd), zinc (Zn), and copper (Cu). Since these proteins are induced on exposure to heavy metals, it is now accepted that they have a detoxifying role during heavy metal toxicity. It has also been suggested that the primary function of Mt is in the homeostasis of the essential metals Zn and Cu. Recently, a role MT in selenium metabolism in primates has been established. Further, MT has gained considerable importance in the clinical disorders related to trace metal metabolism.

Author List

Nath R, Kambadur R, Gulati S, Paliwal VK, Sharma M

Author

Vipin Paliwal PhD Associate Professor in the Physics & Chemistry department at Milwaukee School of Engineering

MESH terms used to index this publication - Major topics in bold

Amino Acid Sequence
Animals
Antineoplastic Agents
Cadmium
Calcium
Chemical Phenomena
Chemistry, Physical
Copper
Gold
Humans
Male
Metallothionein
Models, Biological
Molecular Sequence Data
Zinc