Faculty Collaboration Database

Functional coupling of simultaneous electrical and metabolic activity in the human brain. Hum Brain Mapp 2004 Apr;21(4):257-70

Date

03/24/2004

Pubmed ID

15038007

Pubmed Central ID

PMC6871925

DOI

10.1002/hbm.20004

Scopus ID

2-s2.0-1842778949 (requires institutional sign-in at Scopus site)   188 Citations

Abstract

The relationships between brain electrical and metabolic activity are being uncovered currently in animal models using invasive methods; however, in the human brain this relationship remains not well understood. In particular, the relationship between noninvasive measurements of electrical activity and metabolism remains largely undefined. To understand better these relations, cerebral activity was measured simultaneously with electroencephalography (EEG) and positron emission tomography using [(18)f]-fluoro-2-deoxy-D-glucose (PET-FDG) in 12 normal human subjects during rest. Intracerebral distributions of current density were estimated, yielding tomographic maps for seven standard EEG frequency bands. The PET and EEG data were registered to the same space and voxel dimensions, and correlational maps were created on a voxel-by-voxel basis across all subjects. For each band, significant positive and negative correlations were found that are generally consistent with extant understanding of EEG band power function. With increasing EEG frequency, there was an increase in the number of positively correlated voxels, whereas the lower alpha band (8.5-10.0 Hz) was associated with the highest number of negative correlations. This work presents a method for comparing EEG signals with other more traditionally tomographic functional imaging data on a 3-D basis. This method will be useful in the future when it is applied to functional imaging methods with faster time resolution, such as short half-life PET blood flow tracers and functional magnetic resonance imaging.

Author List

Oakes TR, Pizzagalli DA, Hendrick AM, Horras KA, Larson CL, Abercrombie HC, Schaefer SM, Koger JV, Davidson RJ

Author

Christine Larson PhD Associate Professor in the Psychology department at University of Wisconsin - Milwaukee

MESH terms used to index this publication - Major topics in bold

Adult
Brain
Brain Mapping
Electroencephalography
Energy Metabolism
Female
Fluorodeoxyglucose F18
Glucose
Humans
Male
Middle Aged
Tomography, Emission-Computed