Nifedipine pretreatment reduces vibration-induced vascular damage. Muscle Nerve 2005 Nov;32(5):639-46
Date
07/02/2005Pubmed ID
15991251DOI
10.1002/mus.20388Scopus ID
2-s2.0-27144485778 (requires institutional sign-in at Scopus site) 14 CitationsAbstract
A rat-tail vibration model of hand-arm vibration was employed to test whether preemptive administration of nifedipine (5 mg/kg) to block vasoconstriction prevents vibration-induced arterial damage. The tails of vibrated and nifedipine-pretreated vibrated Sprague-Dawley rats were exposed continuously to 4 h of 60-HZ vibration at 49 m/s(2) rms. In nonvibrated anesthetized rats, the ventral tail arteries were bathed for 15 min in situ in 1 mM epinephrine or 1 mM norepinephrine to induce structural changes indicative of intense vasoconstriction. Arteries were processed for light and electron microscopy 45 min after treatment. Compared to sham control, 4-h vibration significantly (P < 0.01) reduced lumen size, generated endothelial disruption (7.0 +/- 2.6%), elevated nuclear factor of activated T cells c3 (NFATc3) expression in endothelial and smooth muscle cells, and increased smooth muscle cell vacuolization. The findings demonstrate that blockage of vibration-induced vasoconstriction with nifedipine prevents acute vascular damage. Smooth muscle and endothelial cells structurally altered by vasoconstriction are rendered susceptible to damage by vibration.
Author List
Curry BD, Govindaraju SR, Bain JL, Zhang LL, Yan JG, Matloub HS, Riley DAAuthor
Hani S. Matloub MD Professor in the Plastic Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsArteries
Endothelium, Vascular
Male
Models, Animal
Muscle, Smooth, Vascular
NFATC Transcription Factors
Nifedipine
Rats
Rats, Sprague-Dawley
Regional Blood Flow
Tail
Vasoconstriction
Vasodilator Agents
Vibration
