Faculty Collaboration Database

Vibration-induced disruption of retrograde axoplasmic transport in peripheral nerve. Muscle Nerve 2005 Oct;32(4):521-6

Date

06/25/2005

Pubmed ID

15977204

DOI

10.1002/mus.20379

Scopus ID

2-s2.0-25844477039 (requires institutional sign-in at Scopus site)   25 Citations

Abstract

Hand-arm vibration syndrome (HAVS) results from excessive exposure to hand-transmitted vibration. Whether the peripheral nerve damage characteristic of HAVS is a direct result of vibration or is secondary to vascular insufficiency remains unclear. The purpose of this study was to explore the effect of vibration exposure on axoplasmic transport in peripheral nerves and soleus motor neurons. Sciatic nerves and motor neurons from rats following two 5-h periods of vibration exposure demonstrated disruption in retrograde transport compared to normal. After 10 days of vibration (5 h/day), axoplasmic transport failed to recover within 24-48 h in most rats. This study demonstrates that disrupted axoplasmic transport is an early consequence of short-term vibration exposure. The effects of vibration on axoplasmic transport also appear to be cumulative. This study provides a new biological way to evaluate measures to prevent early vibration injury.

Author List

Yan JG, Matloub HS, Sanger JR, Zhang LL, Riley DA

Authors

Hani S. Matloub MD Professor in the Plastic Surgery department at Medical College of Wisconsin
James R. Sanger MD Professor in the Plastic Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Axonal Transport
Axons
Disease Models, Animal
Follow-Up Studies
Male
Molecular Probes
Motor Neurons
Muscle, Skeletal
Peripheral Nerves
Peripheral Nervous System Diseases
Rats
Rats, Sprague-Dawley
Vibration
Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate