Faculty Collaboration Database

ERCC1 protein expression is associated with differential survival in oropharyngeal head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg 2013 Oct;149(4):587-95

Date

07/13/2013

Pubmed ID

23846458

DOI

10.1177/0194599813496522

Scopus ID

2-s2.0-84884335145 (requires institutional sign-in at Scopus site)   9 Citations

Abstract

OBJECTIVE: To investigate ERCC1 protein expression and its relationship to clinical factors and treatment outcomes in patients with head and neck squamous cell carcinoma (HNSCC).

DESIGN: Case series.

SETTING: Tertiary care academic center.

SUBJECTS: One hundred and seventy-six patients diagnosed with HNSCC and treated with intent to cure between 2002 and 2008 were analyzed with respect to clinical data and tumor pathology.

MAIN OUTCOME MEASURES: Tissue microarrays were constructed from tumor blocks and immunohistochemical staining for ERCC1 performed. ERCC1 expression status was dichotomized into high and low using the Allred score. Clinical characteristics of patients with high versus low ERCC1 expression were compared. Distributions of overall survival (OS) and progression-free survival (PFS) were analyzed using the Kaplan-Meier method.

RESULTS: Of 176 patients, ERCC1 showed baseline nuclear staining in 148 patients (84.1%). Lower staining intensity ERCC1 expression was prominent in parabasal cells in the lower half of the epithelium, while at high staining intensity, ERCC1 expression was present throughout the epithelium. The median H-score was 50. No significant differences in age, gender, smoking status, tumor site, or stage were seen between the high and low ERCC1 expression groups. Expression of ERCC1 stratified by tumor site correlates with OS. Patients with oropharyngeal HNSCC and high ERCC1 expression (H-score > 120) were more likely to survive (P < .01) and remain disease free when compared to non-oropharyngeal squamous cell carcinoma (SCCa) patients with high ERCC1 expression despite treatment modality and human papillomavirus virus (HPV) status.

CONCLUSION: Patients with oropharyngeal SCCa and high ERCC1 expression may have better outcomes despite HPV status.

Author List

Patel MR, Zhao N, Ang MK, Stadler ME, Fritchie K, Weissler MC, Zanation AM, Harris SL, Funkhouser WK, Olshan AF, Shores CG, Hayes DN

Author

Michael Stadler MD Associate Dean, Chief Medical Officer, Associate P in the Medical College Physicians Administration department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Alphapapillomavirus
Carcinoma, Squamous Cell
DNA-Binding Proteins
Disease-Free Survival
Endonucleases
Female
Gene Expression Regulation, Neoplastic
Head and Neck Neoplasms
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Laryngeal Neoplasms
Male
Middle Aged
Oropharyngeal Neoplasms
Prognosis
Tissue Array Analysis
Treatment Outcome