Faculty Collaboration Database

The interrelationships of glycemic control measures: HbA1c, glycated albumin, fructosamine, 1,5-anhydroglucitrol, and continuous glucose monitoring. Pediatr Diabetes 2011 Dec;12(8):690-5

Date

04/19/2011

Pubmed ID

21496193

Pubmed Central ID

PMC3193556

DOI

10.1111/j.1399-5448.2011.00764.x

Scopus ID

2-s2.0-82155183113 (requires institutional sign-in at Scopus site)   43 Citations

Abstract

OBJECTIVES: To describe the interrelationships of glycemic control measures: hemoglobin A1c (HbA1c), glycated albumin, fructosamine, 1,5-anhydroglucitrol (1,5-AG), and continuous glucose monitoring (CGM) in children and adolescents with type 1 diabetes.

METHODS: In total, 26 subjects of age 4-17 had HbA1c measurement followed within 14 d by three laboratory measures of glycemia and the collection of CGM glucose data (N = 21).

RESULTS: Glycated albumin and fructosamine levels had a higher correlation with each other than with HbA1c. The correlation of 1,5-AG with HbA1c was lower (absolute r value = 0.25). All four measures had a similar degree of correlation with CGM-measured mean glucose (absolute r value = 0.50-0.56) and with hyperglycemic area under the curve (AUC) at 180 mg/dL (0.50-0.60).

CONCLUSION: Each of the four measures (i.e., HbA1c, glycated albumin, fructosamine, and 1,5-AG) had a similar correlation with mean glucose and hyperglycemic AUC-180. 1,5-AG did not correlate with hyperglycemic AUC-180 better than did HbA1c.

Author List

Beck R, Steffes M, Xing D, Ruedy K, Mauras N, Wilson DM, Kollman C, Diabetes Research in Children Network (DirecNet) Study Group

Author

Rosanna V. Fiallo-Scharer MD Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Blood Glucose
Blood Glucose Self-Monitoring
Child
Child, Preschool
Deoxyglucose
Diabetes Mellitus, Type 1
Female
Fructosamine
Glycation End Products, Advanced
Humans
Male
Serum Albumin