Faculty Collaboration Database

Elevated 12- and 20-hydroxyeicosatetraenoic acid in urine of patients with prostatic diseases. Cancer Lett 2006 Feb 28;233(2):219-25

Date

05/11/2005

Pubmed ID

15882928

DOI

10.1016/j.canlet.2005.03.025

Scopus ID

2-s2.0-33644648950 (requires institutional sign-in at Scopus site)   43 Citations

Abstract

The role of eicosanoids (metabolites of arachidonic acid) in prostate diseases is receiving increased attention. We investigated the relationship between the concentrations of urinary free acids of 12- and 20-hydroxyeicosatetraenoic acids (12- and 20-HETE) and the benign prostatic hypertrophy (BPH) and prostate cancer (Pca). Urinary concentrations of 12-HETE and 20-HETE of BPH and Pca patients were significantly higher than normal subjects. After removal of the prostate gland, the urinary concentrations of these eicosanoids decreased to concentrations similar to the normal subjects. These results suggest that urinary free acids of 12-HETE and 20-HETE indicate an abnormality of the prostate gland.

Author List

Nithipatikom K, Isbell MA, See WA, Campbell WB

Author

William B. Campbell PhD Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
Adult
Aged
Chromatography, Liquid
Humans
Hydroxyeicosatetraenoic Acids
Male
Middle Aged
Prostate
Prostatic Hyperplasia
Prostatic Neoplasms
Spectrometry, Mass, Electrospray Ionization