Diffusion-weighted MRI as a biomarker for treatment response in glioma. CNS Oncol 2012 Nov;1(2):169-80
Date
08/13/2013Pubmed ID
23936625Pubmed Central ID
PMC3734866DOI
10.2217/cns.12.25Scopus ID
2-s2.0-84906738491 (requires institutional sign-in at Scopus site) 44 CitationsAbstract
Diffusion-weighted imaging (DWI) is a powerful MRI method, which probes abnormalities of tissue structure by detecting microscopic changes in water mobility at a cellular level beyond what is available with other imaging techniques. Accordingly, DWI has the potential to identify pathology before gross anatomic changes are evident on standard anatomical brain images. These features of tissue characterization and earlier detection are what make DWI particularly appealing for the evaluation of gliomas and the newer therapies where standard anatomical imaging is proving insufficient. This article focuses on the basic principles and applications of DWI, and its derived parameter, the apparent diffusion coefficient, for the purposes of diagnosis and evaluation of glioma, especially in the context of monitoring response to therapy.
Author List
Schmainda KMAuthor
Kathleen M. Schmainda PhD Professor in the Biophysics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBrain
Brain Neoplasms
Diffusion Magnetic Resonance Imaging
Glioma
Humans
