Medical College of Wisconsin
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Diffusion-weighted MRI as a biomarker for treatment response in glioma. CNS Oncol 2012 Nov;1(2):169-80

Date

08/13/2013

Pubmed ID

23936625

Pubmed Central ID

PMC3734866

DOI

10.2217/cns.12.25

Scopus ID

2-s2.0-84906738491   33 Citations

Abstract

Diffusion-weighted imaging (DWI) is a powerful MRI method, which probes abnormalities of tissue structure by detecting microscopic changes in water mobility at a cellular level beyond what is available with other imaging techniques. Accordingly, DWI has the potential to identify pathology before gross anatomic changes are evident on standard anatomical brain images. These features of tissue characterization and earlier detection are what make DWI particularly appealing for the evaluation of gliomas and the newer therapies where standard anatomical imaging is proving insufficient. This article focuses on the basic principles and applications of DWI, and its derived parameter, the apparent diffusion coefficient, for the purposes of diagnosis and evaluation of glioma, especially in the context of monitoring response to therapy.

Author List

Schmainda KM

Author

Kathleen M. Schmainda PhD Professor in the Biophysics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Brain
Brain Neoplasms
Diffusion Magnetic Resonance Imaging
Glioma
Humans