Bacterial meningitis from Rothia mucilaginosa in patients with malignancy or undergoing hematopoietic stem cell transplantation. Pediatr Blood Cancer 2008 Mar;50(3):673-6
Date
06/26/2007Pubmed ID
17588235DOI
10.1002/pbc.21286Scopus ID
2-s2.0-38549105995 (requires institutional sign-in at Scopus site) 29 CitationsAbstract
Opportunistic infections contribute to morbidity and mortality of patients undergoing hematopoietic stem cell transplantation and treatment for malignancies. Rothia mucilaginosa, a gram-positive bacterium, is responsible for rare, but often fatal meningitis in severely immunocompromised patients. We describe two cases of meningitis from discrete strains of R. mucilaginosa on our pediatric bone marrow transplant unit, summarize the published cases of R. mucilaginosa meningitis in oncology and stem cell transplant patients, and provide updated recommendations regarding the use of antibiotic therapy in this patient population.
Author List
Lee AB, Harker-Murray P, Ferrieri P, Schleiss MR, Tolar JAuthor
Paul D. Harker-Murray MD, PhD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Actinomycetales InfectionsAdolescent
Anti-Bacterial Agents
Ceftazidime
Cerebrospinal Fluid Shunts
Child
Cord Blood Stem Cell Transplantation
Drug Therapy, Combination
Fatal Outcome
Female
Humans
Immunocompromised Host
Leukemia, Megakaryoblastic, Acute
Male
Meningitis, Bacterial
Micrococcaceae
Opportunistic Infections
Postoperative Complications
Rifampin
Sepsis
Thienamycins
Vancomycin