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Bacterial meningitis from Rothia mucilaginosa in patients with malignancy or undergoing hematopoietic stem cell transplantation. Pediatr Blood Cancer 2008 Mar;50(3):673-6

Date

06/26/2007

Pubmed ID

17588235

DOI

10.1002/pbc.21286

Scopus ID

2-s2.0-38549105995 (requires institutional sign-in at Scopus site)   29 Citations

Abstract

Opportunistic infections contribute to morbidity and mortality of patients undergoing hematopoietic stem cell transplantation and treatment for malignancies. Rothia mucilaginosa, a gram-positive bacterium, is responsible for rare, but often fatal meningitis in severely immunocompromised patients. We describe two cases of meningitis from discrete strains of R. mucilaginosa on our pediatric bone marrow transplant unit, summarize the published cases of R. mucilaginosa meningitis in oncology and stem cell transplant patients, and provide updated recommendations regarding the use of antibiotic therapy in this patient population.

Author List

Lee AB, Harker-Murray P, Ferrieri P, Schleiss MR, Tolar J

Author

Paul D. Harker-Murray MD, PhD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Actinomycetales Infections
Adolescent
Anti-Bacterial Agents
Ceftazidime
Cerebrospinal Fluid Shunts
Child
Cord Blood Stem Cell Transplantation
Drug Therapy, Combination
Fatal Outcome
Female
Humans
Immunocompromised Host
Leukemia, Megakaryoblastic, Acute
Male
Meningitis, Bacterial
Micrococcaceae
Opportunistic Infections
Postoperative Complications
Rifampin
Sepsis
Thienamycins
Vancomycin