Continuous in-home monitoring of essential tremor. Parkinsonism Relat Disord 2014 Jan;20(1):37-40
Date
10/16/2013Pubmed ID
24126021Pubmed Central ID
PMC3946846DOI
10.1016/j.parkreldis.2013.09.009Scopus ID
2-s2.0-84892816474 (requires institutional sign-in at Scopus site) 59 CitationsAbstract
BACKGROUND: Essential tremor (ET) is typically measured in the clinic with subjective tremor rating scales which require the presence of a clinician for scoring and are not appropriate for measuring severity throughout the day. Motion sensors can accurately rate tremor severity during a set of predefined tasks in a laboratory.
METHODS: We evaluated the ability of motion sensors to quantify tremor during unconstrained activities at home. 20 ET subjects wore a wireless sensor continuously for up to 10 h daily on two days and completed hourly standardized tremor assessments involving pre-defined tasks. Mathematical models were used to predict tremor rating scores from the sensor data.
RESULTS: At home tremor scores from hourly standardized assessments correlated with at home tremor scores estimated during unconstrained activities immediately following the standardized assessments. The hourly standardized assessments did not significantly fluctuate throughout the day, while fluctuations in the continuous assessments tended to follow changes in voluntary activity level. Both types of tremor ratings (standardized and continuous) showed high day-to-day test-retest reliability with intraclass correlation coefficients ranging from 0.67 to 0.90 for continuous ratings and 0.77 to 0.95 for standardized ratings.
CONCLUSIONS: Results demonstrate the feasibility of continuous monitoring of tremor severity at home, which should provide clinicians with a measure of the temporal pattern of tremor in the context of daily life and serve as a useful tool for the evaluation of novel anti-tremor medications in clinical trials.
Author List
Pulliam CL, Eichenseer SR, Goetz CG, Waln O, Hunter CB, Jankovic J, Vaillancourt DE, Giuffrida JP, Heldman DAAuthor
Sheila Rane Eichenseer MD Assistant Professor in the Neurology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AccelerometryAged
Aged, 80 and over
Biomechanical Phenomena
Essential Tremor
Feasibility Studies
Female
Humans
Male
Middle Aged
Monitoring, Ambulatory
