Faculty Collaboration Database

Feasibility of allogeneic hematopoietic stem cell transplantation for follicular lymphoma undergoing transformation to diffuse large B-cell lymphoma. Leuk Lymphoma 2008 Oct;49(10):1893-8

Date

10/25/2008

Pubmed ID

18949613

DOI

10.1080/10428190802270902

Scopus ID

2-s2.0-55049125260 (requires institutional sign-in at Scopus site)   9 Citations

Abstract

The transformation of follicular lymphoma (FL) to high-grade histology occurs in up to 70% of FL patients. Studies reporting outcomes of transformed FL patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are scant. Eight FL patients with histologically confirmed transformation to diffuse large B-cell lymphoma underwent HSCT at our institution. The median age was 56 years (range 44-63 years). Median follow-up is 60 months. Progression free survival and overall survival at 4-years for patients undergoing allogeneic HSCT is 56% and 66%, respectively. Four patients developed grade II-IV acute GVHD, whereas four patients had extensive chronic GVHD. Day 100 and overall non-relapse mortality rate was 12.5% and 25%, respectively. Allogeneic HSCT appears feasible in patients with transformed FL and is associated with acceptable treatment-related mortality and low relapse rates.

Author List

Hamadani M, Awan FT, Elder P, Lin TS, Porcu P, Benson DM, Blum KA, Devine SM

Author

Mehdi H. Hamadani MD Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Cell Transformation, Neoplastic
Feasibility Studies
Female
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Humans
Lymphoma, Follicular
Lymphoma, Large B-Cell, Diffuse
Male
Middle Aged
Salvage Therapy
Survival Analysis
Transplantation Conditioning
Transplantation, Homologous