High-dose therapy and autologous stem cell transplantation for follicular lymphoma undergoing transformation to diffuse large B-cell lymphoma. Eur J Haematol 2008 Dec;81(6):425-31
Date
09/09/2008Pubmed ID
18774954DOI
10.1111/j.1600-0609.2008.01146.xScopus ID
2-s2.0-56649106241 (requires institutional sign-in at Scopus site) 27 CitationsAbstract
The transformation of follicular lymphoma (FL) to high-grade histology occurs in up to 70% of patients. The role of hematopoietic stem cell transplantation (HSCT) in transformed FL is poorly defined. Twenty-four FL patients with histologically confirmed transformation to diffuse large B-cell lymphoma underwent unpurged autologous HSCT at our institution. Their median age was 56 yr. The median number of prior chemotherapies was 2 (range 1-6). Thirteen patients had residual nodal disease measuring more than 2 cm and four patients had bulky disease at the time of HSCT. Six patients had refractory disease at transplantation. At a median follow-up of 38 months, 3-yr progression-free survival following autologous HSCT was 40%. The 3-yr overall survival was 52%. The cumulative incidence of relapse and non-relapse mortality rate was 41% and 25%, respectively.
Author List
Hamadani M, Benson DM Jr, Lin TS, Porcu P, Blum KA, Devine SMAuthor
Mehdi H. Hamadani MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedAntibodies, Monoclonal
Antibodies, Monoclonal, Murine-Derived
Antineoplastic Agents
Disease-Free Survival
Female
Hematopoietic Stem Cell Transplantation
Humans
Lymphoma, Follicular
Lymphoma, Large B-Cell, Diffuse
Male
Middle Aged
Retrospective Studies
Rituximab
Salvage Therapy
Survival Rate
Transplantation Conditioning
Transplantation, Autologous
