Granulocytic sarcoma manifesting as multiple skeletal lesions. Am J Med Sci 2005 Sep;330(3):139-43
Date
09/22/2005Pubmed ID
16174998DOI
10.1097/00000441-200509000-00008Scopus ID
2-s2.0-25444458899 (requires institutional sign-in at Scopus site) 13 CitationsAbstract
Granulocytic sarcoma is an extramedullary collection of myeloblasts that is usually associated with acute or chronic myeloid leukemia. It can be found in any location throughout the body; however, multifocal skeletal involvement is extremely rare. This report describes a case of granulocytic sarcoma in a 33-year-old man, manifesting as multiple skeletal lesions along with signs of cord compression without any preceding history of myeloid leukemia. Cytogenetic studies revealed t(8,9) translocation, which has never been reported in association with granulocytic sarcoma. The prognostic significance of this finding is unknown. This case report underscores the importance of considering granulocytic sarcoma in the differential diagnosis of spinal tumors, since the tumor may occur before other manifestations of myeloid leukemia are evident.
Author List
Hamadani M, Tfayli A, Sethi S, Awab A, Hamdani NAuthor
Mehdi H. Hamadani MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultBone and Bones
Humans
Immunohistochemistry
Male
Peroxidase
Prognosis
Radionuclide Imaging
Sarcoma, Myeloid
