Faculty Collaboration Database

Effect of contrast leakage on the detection of abnormal brain tumor vasculature in high-grade glioma. J Neurooncol 2014 Feb;116(3):543-549

Date

12/03/2013

Pubmed ID

24293201

Pubmed Central ID

PMC4316680

DOI

10.1007/s11060-013-1318-9

Scopus ID

2-s2.0-84894083764 (requires institutional sign-in at Scopus site)   8 Citations

Abstract

Abnormal brain tumor vasculature has recently been highlighted by a dynamic susceptibility contrast (DSC) MRI processing technique. The technique uses independent component analysis (ICA) to separate arterial and venous perfusion. The overlap of the two, i.e. arterio-venous overlap or AVOL, preferentially occurs in brain tumors and predicts response to anti-angiogenic therapy. The effects of contrast agent leakage on the AVOL biomarker have yet to be established. DSC was acquired during two separate contrast boluses in ten patients undergoing clinical imaging for brain tumor diagnosis. Three components were modeled with ICA, which included the arterial and venous components. The percentage of each component as well as a third component were determined within contrast enhancing tumor and compared. AVOL within enhancing tumor was also compared between doses. The percentage of enhancing tumor classified as not arterial or venous and instead into a third component with contrast agent leakage apparent in the time-series was significantly greater for the first contrast dose compared to the second. The amount of AVOL detected within enhancing tumor was also significantly greater with the second dose compared to the first. Contrast leakage results in large signal variance classified as a separate component by the ICA algorithm. The use of a second dose mitigates the effect and allows measurement of AVOL within enhancement.

Author List

LaViolette PS, Daun MK, Paulson ES, Schmainda KM

Authors

Peter LaViolette PhD Professor in the Radiology department at Medical College of Wisconsin
Eric Paulson PhD Chief, Professor in the Radiation Oncology department at Medical College of Wisconsin
Kathleen M. Schmainda PhD Professor in the Biophysics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Brain Neoplasms
Cerebrovascular Circulation
Contrast Media
Female
Glioma
Humans
Magnetic Resonance Imaging
Male
Microvessels
Middle Aged
Neovascularization, Pathologic
Principal Component Analysis
Young Adult