Faculty Collaboration Database

Peripheral blood pressure changes induced by dobutamine do not alter BOLD signals in the human brain. Neuroimage 2006 Apr 15;30(3):745-52

Date

12/27/2005

Pubmed ID

16376576

DOI

10.1016/j.neuroimage.2005.10.047

Scopus ID

2-s2.0-33645751664 (requires institutional sign-in at Scopus site)   9 Citations

Abstract

In extending the use of functional MRI to neuropharmacology, a primary area of concern is that peripheral blood pressure changes induced by pharmacological agents could independently produce a change in the blood oxygenation level-dependent (BOLD) signal, resulting in difficulties distinguishing or interpreting drug-induced neural activations. In the present study, we utilized intravenous dobutamine, a beta-adrenergic receptor agonist, to increase the mean arterial blood pressure (MABP), while examining the effects of MABP changes on the BOLD signal in cocaine-dependent participants. Dobutamine infusion significantly increased the MABP from 93 +/- 8 mm Hg to 106 +/- 12 mm Hg (P < 0.0005), but did not produce a significant global BOLD signal. Yet, a few voxels in the anterior cingulate showed BOLD signal changes that paralleled the changes in blood pressure (BP). Our observations support the conclusion that following the infusion of psychoactive agents, brain BOLD signals accurately reflect neuronal activity, even in the face of relatively large peripheral cardiovascular effects that transiently increase systemic BP.

Author List

Liu H, Rainey C, Lauer KK, Piacentine L, Bloom A, Risinger R, Ward BD, Stein E, Li SJ

Authors

Kathryn K. Lauer MD Vice Chair, Professor in the Anesthesiology department at Medical College of Wisconsin
Linda Piacentine BS,MS,NP,PhD Assistant Professor in the College of Nursing department at Marquette University

MESH terms used to index this publication - Major topics in bold

Adrenergic beta-Agonists
Adult
Blood Pressure
Cocaine-Related Disorders
Dobutamine
Female
Humans
Magnetic Resonance Imaging
Male
Oxygen