Faculty Collaboration Database

Seropositivity to herpes simplex virus type 2, but not type 1 is associated with premature cardiovascular diseases: a population-based cross-sectional study. Atherosclerosis 2013 Nov;231(1):18-21

Date

10/16/2013

Pubmed ID

24125404

DOI

10.1016/j.atherosclerosis.2013.08.020

Scopus ID

2-s2.0-84885357810 (requires institutional sign-in at Scopus site)   14 Citations

Abstract

OBJECTIVE: Thirty-five years after herpesviruses were suggested to induce atherosclerosis sero-epidemiological evidence on Herpes Simplex Viruses (HSV) remains sparse and controversial. We aimed to investigate the relationship between HSV-1 and HSV-2 infections and cardiovascular diseases (CVD).

METHODS AND RESULTS: A population-based cross-sectional study was conducted among 14,415 participants (mean age 34.3 years, range 20-49) of the National Health and Nutrition Examination Survey 1999-2010. Serum IgG-antibodies to HSV were measured by enzymatic immunodot assay and CVD were self-reported. CVD prevalence was 1.8%; 51.3% of participants were infected with HSV-1, 7.5% with HSV-2, and 15.2% with both. After adjusting for demographics, socioeconomic status, comorbidities, STD, and CVD risk factors, seropositivity to HSV-2 was positively associated with CVD (Odds ratio [OR] 1.56, 95% confidence interval [CI]: 1.09-2.21, P = 0.014), but not with HSV-1 (OR 1.13, 95% CI: 0.79-1.62).

CONCLUSION: HSV-2 may be associated with premature CVD, but not HSV-1.

Author List

Mendy A, Vieira ER, Gasana J

Author

Janvier Gasana MD, MPH, PhD Adjunct Associate Professor in the Institute for Health and Equity department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Cardiovascular Diseases
Cross-Sectional Studies
Female
Herpes Simplex
Herpesvirus 1, Human
Herpesvirus 2, Human
Humans
Immunoglobulin G
Male
Middle Aged
Nutrition Surveys
Risk Factors
Seroepidemiologic Studies
United States