Seropositivity to herpes simplex virus type 2, but not type 1 is associated with premature cardiovascular diseases: a population-based cross-sectional study. Atherosclerosis 2013 Nov;231(1):18-21
Date
10/16/2013Pubmed ID
24125404DOI
10.1016/j.atherosclerosis.2013.08.020Scopus ID
2-s2.0-84885357810 (requires institutional sign-in at Scopus site) 15 CitationsAbstract
OBJECTIVE: Thirty-five years after herpesviruses were suggested to induce atherosclerosis sero-epidemiological evidence on Herpes Simplex Viruses (HSV) remains sparse and controversial. We aimed to investigate the relationship between HSV-1 and HSV-2 infections and cardiovascular diseases (CVD).
METHODS AND RESULTS: A population-based cross-sectional study was conducted among 14,415 participants (mean age 34.3 years, range 20-49) of the National Health and Nutrition Examination Survey 1999-2010. Serum IgG-antibodies to HSV were measured by enzymatic immunodot assay and CVD were self-reported. CVD prevalence was 1.8%; 51.3% of participants were infected with HSV-1, 7.5% with HSV-2, and 15.2% with both. After adjusting for demographics, socioeconomic status, comorbidities, STD, and CVD risk factors, seropositivity to HSV-2 was positively associated with CVD (Odds ratio [OR] 1.56, 95% confidence interval [CI]: 1.09-2.21, P = 0.014), but not with HSV-1 (OR 1.13, 95% CI: 0.79-1.62).
CONCLUSION: HSV-2 may be associated with premature CVD, but not HSV-1.
Author List
Mendy A, Vieira ER, Gasana JAuthor
Janvier Gasana MD, MPH, PhD Adjunct Associate Professor in the Institute for Health and Equity department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultCardiovascular Diseases
Cross-Sectional Studies
Female
Herpes Simplex
Herpesvirus 1, Human
Herpesvirus 2, Human
Humans
Immunoglobulin G
Male
Middle Aged
Nutrition Surveys
Risk Factors
Seroepidemiologic Studies
United States