Low blood lead concentrations and thyroid function of American adults. Int J Environ Health Res 2013 Dec;23(6):461-73
Date
01/18/2013Pubmed ID
23323812DOI
10.1080/09603123.2012.755155Scopus ID
2-s2.0-84889666738 (requires institutional sign-in at Scopus site) 9 CitationsAbstract
Lead is often present in our environment, but its effect on thyroid function is still unclear. In this study, multiple linear regressions were performed between log-transformed blood lead levels and thyroid function parameters of 4652 adults from the 2007-2008 National Health and Nutrition Examination Survey. The models were adjusted for age, gender, race/ethnicity, smoking, alcohol consumption, body mass index, physical activity, iodine intake, medications, and bone mineral density. Blood lead concentrations (mean: 1.52 ± 1.20 μg/dL [range 0.18-33.12]) were inversely associated with total thyroxine (regression coefficients [β]: -0.22 [95% CI: -0.34, -0.09] in the general population, but were not correlated with thyroid stimulating hormone, total or free triiodothyronine, nor free thyroxine. Blood lead may have no effect on the thyroid function; however, it could be associated with decreased concentrations in thyroid-binding proteins.
Author List
Mendy A, Gasana J, Vieira ERAuthor
Janvier Gasana MD, MPH, PhD Adjunct Associate Professor in the Institute for Health and Equity department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAged
Cross-Sectional Studies
Environmental Exposure
Environmental Monitoring
Female
Humans
Immunoassay
Lead
Linear Models
Male
Mass Spectrometry
Middle Aged
Nutrition Surveys
Thyrotropin
Thyroxine
Triiodothyronine
United States
Young Adult
