Risk Factors and Treatment Strategies in Patients With Retinal Vascular Occlusions. Clin Appl Thromb Hemost 2015 Oct;21(7):672-7
Date
12/18/2013Pubmed ID
24335246DOI
10.1177/1076029613513320Scopus ID
2-s2.0-84940846964 (requires institutional sign-in at Scopus site) 15 CitationsAbstract
Retinal vein occlusion (RVO) and retinal artery occlusion (RAO) cause significant visual impairment. The role of thrombophilia and cardiovascular testing is uncertain, and optimal treatment strategies have not been determined. We reviewed medical records of 39 patients with RVO and RAO (23 women and 16 men). Thrombophilia and cardiovascular evaluations were performed and outcomes were reviewed. In all, 24 (61.5%) patients had at least 1 thrombophilia. Elevated factor VIII levels were found in RVO (n = 5) but not in RAO. There are no other significant differences in thrombophilias in RVO compared to those in RAO. Most patients had hypertension(41.2% RAO and 55% RVO) and hyperlipidemia (35.5% RAO and 81.8% RVO). In all, 4 women were using oral contraceptives, 2 were pregnant or postpartum. Follow-up data was available for 28 patients (13 RAO, 15 RVO). Nineteen were treated with aspirin, four with warfarin, and one with low molecular weight heparin. Eight patients reported improvement in vision at time of follow-up (5 RAO, 3 RVO). Multiple risk factors are associated with RVO and RAO, and a complete assessment should include thrombophilia and cardiovascular studies.
Author List
Chapin J, Carlson K, Christos PJ, DeSancho MTAuthor
Karen-Sue B. Carlson MD, PhD Associate Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAged
Aged, 80 and over
Aspirin
Female
Humans
Hyperlipidemias
Hypertension
Male
Middle Aged
Postpartum Period
Pregnancy
Pregnancy Complications
Retinal Vein Occlusion
Retrospective Studies
Risk Factors
Thrombophilia
Warfarin