Faculty Collaboration Database

Incidence and survival of desmoplastic melanoma in the United States, 1992-2007. J Cutan Pathol 2011 Aug;38(8):616-24

Date

04/27/2011

Pubmed ID

21518379

DOI

10.1111/j.1600-0560.2011.01704.x

Scopus ID

2-s2.0-79960554588 (requires institutional sign-in at Scopus site)   70 Citations

Abstract

BACKGROUND: Desmoplastic melanoma (DM) represents a relatively rare malignancy. The aim of this study was to describe the incidence and survival of DM in the United States.

METHODS: Incidence and survival data were obtained from the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) program, 1992-2007. Kaplan-Meier and Cox proportional hazards regression methods were used to calculate the survival rates and hazard ratios for DM-specific death.

RESULTS: We identified 1129 DM patients from SEER 13 registries, with 64% in men, 37% in women and most (96.8%) occurring in White populations. The incidence rates per 1,000,000 were 1.3 (female), 3.0 (male) and 2.0 (both). The annual percentage change for incidence was 4.6 (95% confidence interval: 2.9-6.5) from 1992 to 2007. The 5-year and 10-year DM-specific survival rates from SEER 17 registries were 84.8 and 79.2%. The 5-year DM-specific survival rates by stage ranged from 90.9% (local) to 51.5% (distant). Independent predictors of mortality from DM included age, anatomic site, thickness, ulceration, lymph node and surgery.

CONCLUSIONS: The incidence of DM has been increasing steadily over the past 15 years. Older age, anatomic site of the head and neck, tumor thickness >2 mm, ulceration, lymph node involvement and non-receipt of surgery are associated with lower survival.

Author List

Feng Z, Wu X, Chen V, Velie E, Zhang Z

Author

Ellen Velie PhD, MPH Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Aged
Aged, 80 and over
Child
Female
Head and Neck Neoplasms
Humans
Incidence
Kaplan-Meier Estimate
Lymph Nodes
Male
Melanoma
Middle Aged
Proportional Hazards Models
Registries
Skin Neoplasms
Survival Rate
United States
Young Adult