Lymph node ratio influence on risk of head and neck cancer locoregional recurrence after initial surgical resection: implications for adjuvant therapy. Head Neck 2015 Jun;37(6):777-82
Date
03/07/2014Pubmed ID
24596123DOI
10.1002/hed.23662Scopus ID
2-s2.0-84929909838 (requires institutional sign-in at Scopus site) 58 CitationsAbstract
BACKGROUND: The purpose of this study was to determine if lymph node ratio is associated with locoregional recurrence for patients with oral cavity or laryngeal cancer treated with initial surgical management.
METHODS: The study included 350 patients with oral cavity (73%) or laryngeal cancer (27%) who underwent initial surgery. All analyses were multivariable, adjusting for primary site, pathologic prognostic factors, and adjuvant therapy.
RESULTS: Lymph node ratio was significantly associated with locoregional recurrence, in which each 1% increase in lymph node ratio had an adjusted hazard ratio (HR) for locoregional recurrence of 1.02 (95% confidence interval [CI], 1.002-1.042; p = .05). Lymph node ratio was also associated with OS, in which each 1% increase in lymph node ratio had an adjusted HR for death of 1.028 (95% CI, 1.012-1.045; p = .001).
CONCLUSION: Adjusting for pathologic factors and adjuvant therapy, lymph node ratio was found to be an independent prognostic factor for locoregional recurrence and overall survival (OS). Patients with lymph node ratio ≥20% are at high risk of locoregional recurrence and death, and may be considered for adjuvant chemoradiation.
Author List
Prabhu RS, Hanasoge S, Magliocca KR, Hall WA, Chen SA, Higgins KA, Saba NF, El-Deiry M, Grist W, Wadsworth JT, Chen AY, Beitler JJAuthor
William Adrian Hall MD Professor in the Radiation Oncology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Chemoradiotherapy, AdjuvantDatabases, Factual
Disease-Free Survival
Female
Head and Neck Neoplasms
Humans
Laryngeal Neoplasms
Lymphatic Metastasis
Male
Mouth Neoplasms
Multivariate Analysis
Neck Dissection
Neoplasm Invasiveness
Neoplasm Recurrence, Local
Neoplasm Staging
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Retrospective Studies
Risk Assessment
Survival Analysis
Treatment Outcome
