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Intracranial cortical responses during visual-tactile integration in humans. J Neurosci 2014 Jan 01;34(1):171-81

Date

01/02/2014

Pubmed ID

24381279

Pubmed Central ID

PMC3866483

DOI

10.1523/JNEUROSCI.0532-13.2014

Scopus ID

2-s2.0-84891452687   35 Citations

Abstract

Sensory integration of touch and sight is crucial to perceiving and navigating the environment. While recent evidence from other sensory modality combinations suggests that low-level sensory areas integrate multisensory information at early processing stages, little is known about how the brain combines visual and tactile information. We investigated the dynamics of multisensory integration between vision and touch using the high spatial and temporal resolution of intracranial electrocorticography in humans. We present a novel, two-step metric for defining multisensory integration. The first step compares the sum of the unisensory responses to the bimodal response as multisensory responses. The second step eliminates the possibility that double addition of sensory responses could be misinterpreted as interactions. Using these criteria, averaged local field potentials and high-gamma-band power demonstrate a functional processing cascade whereby sensory integration occurs late, both anatomically and temporally, in the temporo-parieto-occipital junction (TPOJ) and dorsolateral prefrontal cortex. Results further suggest two neurophysiologically distinct and temporally separated integration mechanisms in TPOJ, while providing direct evidence for local suppression as a dominant mechanism for synthesizing visual and tactile input. These results tend to support earlier concepts of multisensory integration as relatively late and centered in tertiary multimodal association cortices.

Author List

Quinn BT, Carlson C, Doyle W, Cash SS, Devinsky O, Spence C, Halgren E, Thesen T

Author

Chad Carlson MD Professor in the Neurology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Cerebral Cortex
Electroencephalography
Humans
Photic Stimulation
Reaction Time
Touch
Vibration
Visual Perception
Young Adult